Human papillomavirus lesions in 16 MS patients treated with fingolimod: Outcomes and vaccination - DocWire News

Human papillomavirus lesions in 16 MS patients treated with fingolimod: Outcomes and vaccination - DocWire News

Human papillomavirus lesions in 16 MS patients treated with fingolimod: Outcomes and vaccination - DocWire News

Posted: 24 Feb 2021 10:00 PM PST

This article was originally published here

Mult Scler. 2021 Feb 25:1352458521991433. doi: 10.1177/1352458521991433. Online ahead of print.

ABSTRACT

Few cases of human papillomavirus (HPV) diseases have been reported in multiple sclerosis (MS) patients treated with fingolimod. We describe a case series of 16 MS patients (11 women, 5 men) developing HPV lesions after the onset of fingolimod, without previous HPV history. Fingolimod had to be discontinued in six patients. Six patients received vaccination for HPV, with good tolerance. Our report highlights that systematic HPV screening and discussion about HPV vaccination before fingolimod onset are crucial. In case of occurrence of HPV lesions during fingolimod treatment, a comprehensive workup of HPV disease is necessary, with discussion of HPV vaccination to prevent secondary lesions. Prevalence studies of HPV lesions are needed in MS patients with the different disease-modifying therapies.

PMID:33629615 | DOI:10.1177/1352458521991433

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