Just one dose of the HPV vaccine may be enough to lower cancer rates - New Scientist News

Just one dose of the HPV vaccine may be enough to lower cancer rates - New Scientist News


Just one dose of the HPV vaccine may be enough to lower cancer rates - New Scientist News

Posted: 29 Jul 2019 03:42 AM PDT

Cervical cancer rates are in decline thanks to the HPV vaccine
Cervical cancer rates are in decline thanks to the HPV vaccine

Matthew Busch for The Washington Post via Getty Images

A single dose of the human papillomavirus (HPV) vaccine seems to be almost as good as two or three injections at preventing cervical cancer. The finding may make reaching the World Health Organization's goal of eliminating cervical cancer easier than initially thought.

Many people catch HPV through sexual activity, but the body's immune system can usually wipe the virus out within a year or two. However, when HPV infections persist they can eventually cause cancer. The virus is responsible for more than 99 per cent of cervical cancers, as well as causing vaginal, vulval, anal and penile cancers, and genital warts.

In 2007, Australia rolled out the world's first national HPV programme, providing girls in schools with three free shots of the vaccine each. The injection is now offered to boys too, and the vaccine – which has been improved to protect against nine strains of HPV – is now usually given in two doses.

Advertisement

To understand how different doses of the vaccine affect the risk of developing cervical cancer, Julia Brotherton at the VCS Foundation in Australia and her colleagues analysed cervical screening data from a quarter of a million Australian women who were eligible for the vaccination.

During the study, sexually active women were encouraged to have a Pap smear test every two years to screen for cellular changes on the cervix that might be a sign of cancer.

Analysing registers of HPV vaccinations and cervical cancer cases, the team found that women who had received three doses of the vaccine were 41 per cent less likely to have these cellular changes – known as precancerous lesions – than unvaccinated women. Women who had been given one or two doses of the vaccine were, respectively, 35 and 39 per cent less likely than unvaccinated women to have these lesions.

This suggests that even one dose of the vaccine can be enough to help lower the incidence of cervical cancer. Administering a one-dose vaccination campaign would be cheaper and easier to administer than a multi-dose programme.

The finding could be particularly useful in developing nations, as these have the highest burden of cervical cancer but the least access to vaccines.

Journal reference: Papillomavirus Research, DOI: 10.1016/j.pvr.2019.100177

More on these topics:

HealthWatch: Wipe Out HPV With New Vaccine - WeAreGreenBay.com

Posted: 10 Jul 2019 12:00 AM PDT

Health Watch

Posted: Updated:

ANN ARBOR, Mich. (Ivanhoe Newswire) — Once someone is infected with the human papillomavirus or HPV, there's been absolutely nothing that cleared the infection until now. Researchers say they've had success in phase two trials of a new vaccine that helps the body rid itself of the virus.
For Sandy LaLonde, cancer was the last thing she was thinking about in her early thirties, until months of irregular periods convinced her to see her doctor for testing.
"She said we have bad news. Your high-risk HPV test came back positive and we're pretty sure you have cervical cancer," LaLonde said.
The cancer was stage two-a and had spread. Sandy needed eight rounds of chemo and 25 rounds of external radiation to treat it. Diane Harper, MD, MPH, MS, Senior Associate Director, MICHR, Professor, Family Medicine and Obstetrics and Gynecology at the University of Michigan is studying a new therapy that she hopes will wipe out cervical cancer by eliminating the HPV virus that can cause it.
Dr. Harper said, "Unlike chlamydia or gonorrhea where you can take an antibiotic and get cured, we don't have anything that will get rid of HPV."
Researchers enrolled 200 women with pre-cancerous cervical lesions and gave them three injections one week apart. The therapy was a protein that triggered an immune response.
Dr. Harper said, "It activates the immune system to go in and find the cells that are infected with HPV or the cells that have started to change because of HPV and attack them."
At the end of six months between 25 and 33 percent of the participants were cleared of lesions and HPV.
"I think having the ability to clear the body of HPV is amazing because just because they don't have cancer from it doesn't mean they don't have a whole host of other complications," said LaLonde.
Dr. Harper says it's important to note that the vaccine researchers are testing is different from Gardasil, the vaccine given to preteens to prevent HPV. The vaccine that is being tested clears tissue that already has HPV. Additional trials are needed before this new vaccine could be considered by the FDA for approval.
Contributors to this news report include: Cyndy McGrath, Field Producer; Jamison Koczan, Editor; and Kirk Manson, Videographer.

Free weekly e-mail on Medical Breakthroughs from Ivanhoe. To sign up: http://www.ivanhoe.com/ftk

MEDICAL BREAKTHROUGHS
RESEARCH SUMMARY

TOPIC: WIPE OUT HPV WITH NEW VACCINE
REPORT: MB #4596

BACKGROUND: HPV stands for human papillomavirus. It's the most common sexually transmitted infection. HPV is usually harmless and goes away by itself, but some types can lead to cancer or genital warts. There's no cure for HPV. But there's a lot you can do to keep HPV from having a negative impact on your health. There are vaccines that can help protect you from ever getting certain types of HPV. Genital warts can be removed by your nurse or doctor. High-risk HPV can usually be easily treated before it turns into cancer, which is why regular Pap/HPV tests are so important. While condoms and dental dams don't offer complete protection, they can help lower your chances of getting HPV.
(Source: https://www.plannedparenthood.org/learn/stds-hiv-safer-sex/hpv)

CANCERS: High-risk HPV is more likely to cause cancer. For most people, the immune system is able to get rid of this type of infection. But some people develop a lasting infection. Over many years, the infection transforms normal cells into precancerous lesions or cancer. HPV infection causes nearly all cervical cancers. Of the cervical cancers related to HPV, about 70% are caused by 2 types: HPV-16 or HPV-18. Smoking may increase the risk of cervical cancer for women who have HPV. Although almost all cervical cancers are caused by HPV, it is important to remember that most genital HPV infections will not cause cancer. Next is oral cancer. HPV can cause cancer of the mouth and tongue. It can also cause cancer of the oropharynx. This is the middle part of the throat, from the tonsils to the tip of the voice box. These HPV-related cancers are increasing in men and women. Changes in sexual behavior, including an increase in oral sex, may be contributing to the increase. Also, HPV is associated with less common cancers, including anal cancer, vulvar and vaginal cancers in women, and penile cancer in men.
(Source: https://www.cancer.net/navigating-cancer-care/prevention-and-healthy-living/hpv-and-cancer)

NEW RESEARCH: Diane Harper, MD, MPH, MS, Senior Associate Director, MICHR, Professor, Family Medicine and Obstetrics and Gynecology at the University of Michigan talked about next steps for the new therapy: "The next steps for this is to figure out do we want to tweak the molecule to see if we can get a higher coverage rate? Or do we combine this with something else to be able to get a better cure, or potentially, such as in head and neck cancer, can we combine this with a chemotherapeutic agent in people who already have cancer to help their cure rates become even better."
(Source: Diane Harper, MD, MPH, MS)

FOR MORE INFORMATION ON THIS REPORT, PLEASE CONTACT:

Ian Demsky, PR
734-945-7189
idemsky@med.umich.edu

If this story or any other Ivanhoe story has impacted your life or prompted you or someone you know~to seek or change treatments, please let us know by contacting Marjorie Bekaert Thomas at mthomas@ivanhoe.com

HPV Testing & PAP Test Market Unit Sales to Witness Significant Growth in the Near Future - Market Reports

Posted: 31 Jul 2019 06:59 AM PDT

Global HPV Testing & Pap Test Market, By Test Type ((HPV Testing), Follow-Up HPV Testing, Co-Testing, Primary HPV Testing, PAP Test)), Application (Cervical Cancer Screening, Vaginal Cancer Screening), End Users (Laboratories, Hospitals, Physicians' Offices Clinics), Geography (North America, South America, Europe, Asia-Pacific, Middle East and Africa)– Industry Trends and Forecast to 2025

The Global HPV Testing & PAP Test Market is expected to reach USD 5840.7 million by 2025, growing at a CAGR of 6.6% during the forecast period of 2018 to 2025. The upcoming market report contains data for historic year2016, the base year of calculation is 2016 and the forecast period is 2018 to 2025.

Request For Report Sample: http://www.marketgrowthanalysis.com/reports/sample/213

The Papanicolaou test is a method of screening out cervical that is utilized for detecting potentially pre-cancerous and cancerous processes in the cervix (opening of the womb or uterus). Irregular findings are usually followed up by more sensitive diagnostic tests and based on the need interventions that prevent progression to cervical cancer are implemented. The HPV test market is growing due to various factors such as growing population, rising number of cervical cancer cases, growing awareness of cervical cancer screening programs, and government initiative. The Cervical cancer remains is one of the major causes of cancer-related deaths in women. All such cancers originate from Human Papillomavirus (HPV) infection. However, the presence of HPV is not sufficient for disease; most women clear the virus without treatment. Various developments are made by the key players for the improvement of this test In April 2018, QIAGEN N.V. launched two novel liquid biopsy panels to evaluate circulating tumor cells (CTCs) in the growing field of research into molecular mechanisms in prostate and lung cancers. The AdnaTest ProstateCancerPanel AR-V7 Kit and AdnaTest LungCancer Kit will be introduced at the American Association for Cancer Research (AACR) 2018. Thus, in the presence of all these factors , the market will grow rapidly.

Market Segmentation: The global HPV testing & PAP test market is segmented based on test type, end user, application, and geographical segments. On the basis of test type, the market is classified into HPV testing, follow-up HPV testing, co-testing, primary HPV testing, PAP test. On the basis of application, the market is classified into cervical cancer screening, vaginal cancer screening. On the basis of end users, the market is segmented into laboratories, hospitals, physicians' offices and clinics.

Based on geography, the market report covers data points for 28 countries across multiple geographies namely North America & South America, Europe, Asia-Pacific and, Middle East & Africa. Some of the major countries covered in this report are U.S., Canada, Germany, France, U.K., Netherlands, Switzerland, Turkey, Russia, China, India, South Korea, Japan, Australia, Singapore, Saudi Arabia, South Africa and, Brazil among others.

Get Complete ToC with Tables and Figures at : http://www.marketgrowthanalysis.com/reports/toc/213

Some of the major players operating in the global HPV testing & PAP test market are Abbott Laboratories, Qiagen N.V., Roche Diagnostics, Hologic, Inc., Becton, Dickinson and Company, Quest Diagnostics, Onco Health Corporation, Seegene, Inc., Femasys Inc., Arbor Vita Corporation, QiagenN. V.,Hologic, Inc., Roche Holding AG, Abbott Laboratories, and Becton, Dickinson, Qiagen N.V., Hologic Inc., and Company among others

Comments

Popular posts from this blog

Effect of a board game on imprisoned women's knowledge about ... - BMC Public Health

Herpes Simplex: Two Types, Comparison Chart, Prevention - Verywell Health

The 5 Best OTC Cold Sore Treatments of 2024 - Health.com