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Showing posts from May, 2024

Catching Up on HPV Testing in Those Over 65 - National Cancer Institute (.gov)

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September 1, 2023 , by Linda Wang For some individuals in their late 60s, it may be worthwhile to get "catch-up" HPV testing, according to findings from a large study. Credit: iStock Testing for the presence of cancer-causing types of the human papillomavirus (HPV) is now a standard part of screening for cervical cancer, some times with simultaneous Pap tests (known as co-testing). But cervical cancer screening is recommended to stop at age 65 in many places and, for a variety of reasons, many older adults stop getting screened for cervical cancer well before that age.  Results from a population-based study conducted in Denmark, however, suggest that it may be worthwhile for ...
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HPV can cause numerous kinds of cancer, yet many people don't realize it - NBC News

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A majority of Americans are unaware that HPV, the most common sexually transmitted infection in the U.S., can cause a number of major cancers, a new study found. Researchers were surprised over one finding in particular: a decline in awareness that HPV, human papillomavirus, is linked to cervical cancer. Nearly all sexually active women and men become infected with HPV at some point, according to the Centers for Disease Control and Prevention. According to CDC estimates, currently more than 42 million Americans carry at least one strain of HPV. About 13 million people are infected each year. In the new study, which will be presented Tuesday at the American Association for Cancer Research's annual meeting, researchers analyzed nationally representative survey data collected by the Health Information National Trends Survey that monitored U.S. adults' knowledge about the virus's connection to cancer. There were about 2,000 to 2,300 annual respondents to the survey, including f...

Sexually transmitted infections (STIs) - World Health Organization (WHO)

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Key facts More than 1 million curable sexually transmitted infections (STIs) are acquired every day worldwide in people 15–49 years old, the majority of which are asymptomatic. In 2020 there were are an estimated 374 million new infections in people 15–49 years with 1 of 4 curable STIs: chlamydia, gonorrhoea, syphilis and trichomoniasis. An estimated 8 million adults between 15 and 49 years old were infected with syphilis in 2022. More than 500 million people aged 15–49 years are estimated to have a genital infection with herpes simplex virus (HSV or herpes) (1) . Human papillomavirus (HPV) infection is associated with over 311 000 cervical cancer deaths each year (2) . 1.1 million pregnant women were estimated to be infected with syphilis in 2022, resulting in over 390 000 adverse birth outcomes. STIs have a direct impact on sexual and reproductive health through stigmatization, infertility, cancers and pregnancy complications and ...

HLA-class II restricted TCR targeting human papillomavirus type 18 E7 induces solid tumor remission in mice - Nature.com

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Abstract T cell receptor (TCR)-engineered T cell therapy is a promising potential treatment for solid tumors, with preliminary efficacy demonstrated in clinical trials. However, obtaining clinically effective TCR molecules remains a major challenge. We have developed a strategy for cloning tumor-specific TCRs from long-term surviving patients who have responded to immunotherapy. Here, we report the identification of a TCR (10F04), which is human leukocyte antigen (HLA)-DRA/DRB1*09:01 restricted and human papillomavirus type 18 (HPV18) E7 84-98 specific, from a multiple antigens stimulating cellular therapy (MASCT) benefited metastatic cervical cancer patient. Upon transduction into human T cells, the 10F04 TCR demonstrated robust antitumor activity in both in vitro and in vivo models. Notably, the TCR effectively redirected both CD4 + and CD8 + T cells to specifically recognize tumor cells and induced multiple cytokine secretion along with durable antitumor activity and outstanding ...

5 Skin Infections You Can Get From the Gym - Health.com

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What kind of rash can you get from a gym? You may catch several types of skin infections from the gym, including a staph infection and ringworm. Research has found that bacteria live on 10% to 30% of gym surfaces, such as equipment, the floor, and yoga mats. Simple actions can save you from common skin infections and other illnesses that easily spread while you sweat. Read on to learn about skin infections you can catch at the gym and ways to prevent them. You might contract a skin infection through contact with different surfaces at the gym. Certain types of bacteria, viruses, and fungi thrive in warm, moist environments, including: Bottoms of smelly gym bags Floors of community showers Insides of running shoes Skin infections that spread through the air can also occur. A study published in 2018 found that germs can spread easily through the air if there's a lot of carbon dioxide, such as when a lot of people are exercising and breathing heavily. ...

Sexually transmitted infections (STIs) - World Health Organization (WHO)

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Key facts More than 1 million curable sexually transmitted infections (STIs) are acquired every day worldwide in people 15–49 years old, the majority of which are asymptomatic. In 2020 there were are an estimated 374 million new infections in people 15–49 years with 1 of 4 curable STIs: chlamydia, gonorrhoea, syphilis and trichomoniasis. An estimated 8 million adults between 15 and 49 years old were infected with syphilis in 2022. More than 500 million people aged 15–49 years are estimated to have a genital infection with herpes simplex virus (HSV or herpes) (1) . Human papillomavirus (HPV) infection is associated with over 311 000 cervical cancer deaths each year (2) . 1.1 million pregnant women were estimated to be infected with syphilis in 2022, resulting in over 390 000 adverse birth outcomes. STIs have a direct impact on sexual and reproductive health through stigmatization, infertility, cancers and pregnancy complications and ...